Research and Publications

MR Neurography and Diffusion Tensor Imaging (DTI) are novel methods used to image peripheral nerves in the body and to image neural tracts in the brain.
Both MR Neurography and DTI have been validated as indispensable clinical diagnostic methods that provide reliable anatomical pathological information, with no other diagnostic method to rival its utility.
Research is ongoing in this exciting field where it is possible to use MRI scanning via MR Neurography and DTI to provide detailed images of nerves as well as neural tracts in the brain which serves an integral role in diagnostic processes.
Below is a list of selected publications from Dr. Filler:
Howe FA, Filler AG, Bell BA, Griffiths JR. Magnetic resonance neurography. Magn. Reson. Med. 28: 328-338 (1992). (PMID: 1461131)
Filler AG, Howe FA, Hayes CE, Kliot M, Winn HR, Bell BA, Griffiths JR, Tsuruda JS. Magnetic resonance neurography. Lancet 341:659-661 (1993). (PMID: 8095572)
Filler AG. Reverse transcriptase microassay. Matrix Application Notes, Packard Instrument Company. PAN0035/MAN-016:1-8 (1993).
Filler AG. Axonal transport and MRI: prospects for contrast agent development. JMRI 4:259-267 (1994). (PMID: 7520308)
Howe FA, Saunders D, Filler AG, McLean MA, Heron C, Brown MM, Griffiths JR. Magnetic resonance neurography of the median nerve. Brit. J. Radiol. 67:1169-1172 (1994). (PMID: 7874414)
Filler AG, Britton JA, Uttley D, Marsh HT. Adult post-repair myelo-meningocoele & tethered cord syndrome: Good surgical outcome after abrupt neurological decline. Brit. J. Neurosurg. 9:659-666 (1995). (PMID: 8561939)
Britz GW, Dailey AT, West GA, Kuntz C, Grant GA, Filler AG, Tsuruda JS, Goodkin R, Haynor DR, Maravilla K, Kliot M. Magnetic resonance imaging in the evaluation and treatment of peripheral nerve problems. Perspectives in Neurosurgery 6:53-66 (1995).
Dailey AT, Tsuruda JS, Goodkin R, Haynor DR, Filler AG, Hayes CE, Kliot M. Magnetic resonance neurography for cervical radiculopathy: a preliminary report. Neurosurgery 38:488-492 (1996). (PMID: 8837800)
Filler AG, Kliot M, Hayes CE, Howe FA, Saunders DE, Bell BA, Winn HR, Griffiths JR, Tsuruda JS. Application of magnetic resonance neurography in the evaluation of patients with peripheral nerve pathology. Journal of Neurosurgery 85:299-309 (1996). (PMID: 8755760)
Kuntz C, Blake L, Britz G, Filler A, Goodkin R, Tsuruda J, Hayes C, Maravilla K, Kliot M. Magnetic resonance neurography of peripheral nerve lesions in the lower extremity. Neurosurgery 39:750-757 (1996). (PMID: 8880769)
Hayes CE, Tsuruda JS, Mathis CM, Maravilla KR, Kliot M, and Filler AG. Brachial plexus: MR imaging with a dedicated phased array surface coils. Radiology 203:286-289 (1997). (PMID: 9122409)
Dailey A, Tsuruda JS, Filler AG, Maravilla K, Goodkin R, Kliot M. Magnetic resonance neurography of peripheral nerve degeneration and regeneration. Lancet 350: 1221-1222 (1997). (PMID: 9652565)
Johnson, JP, Ahn SS, Choi WC, Masciopinto JE, Kim KD, Filler AG, DeSalles AAF. Thoracoscopic sympathectomy: techniques and outcomes. Neurosurgical Focus 4 (2): Article4 (1998). (PMID: 17206769)
Johnson JP, Filler AG, McBride DC, Batzdorf U. Anterior cervical foraminotomy for unilateral radicular disease. Spine 25 (8): 905-909 (2000). (PMID: 10767800)
Johnson JP, Filler AG, McBride DC. Endoscopic thoracic discectomy. Neurosurg. Focus 9(4): Article 11 (2000). (PMID: 16833241)
Filler AG, Maravilla KR, Tsuruda JS. MR Neurography and muscle MR imaging for image diagnosis of disorders affecting the peripheral nerves and musculature. Neurologic Clinics 22(3):643-682, (2004). (PMID: 15207879)
Filler AG, Haynes J, Jordan S, Prager J, Villablanca JP, Farahani K, McBride DQ, Tsuruda JS, Morisoli B, Batzdorf U, Johnson JP. Sciatica of Non-Disk Origin & Piriformis Syndrome: Diagnosis by MR Neurography and Interventional MRI with Outcome Study of Resulting Treatment. Journal of Neurosurgery –Spine 2:99-115 (2005). (PMID: 15739520)
Filler AG. The emergence and optimization of upright posture among hominiform hominoids and the evolutionary pathophysiology of back pain. Neurosurgical Focus 23(1):E4 (2007). (PMID: 17961059)
Filler AG. The first recorded neurosurgical operation – An historical hypothesis: Isis, Osiris, Thoth & the origin of the djed cross spinal symbol. Neurosurgical Focus 23(1):E6 (2007). (PMID: 17961051)
Filler AG. Homeotic evolution in the Mammalia: Diversification of Therian axial seriation and the morphogenetic basis of human origins. PLOS ONE 2(10): e1019, (2007). (PMID: 17925867)
Filler AG. Diagnosis and management of pudendal nerve entrapment syndromes: Impact of MR Neurography and open MR-guided injections. Neurosurgery Quarterly 18:1-6 (2008).
Filler AG. Piriformis and related entrapment syndromes: Diagnosis and management. Neurosurgery Clinics of North America. 19:609-622, (2008). (DOI: 10.1016/ (PMID: 19010285)
Filler AG. Diagnosis and treatment of pudendal nerve entrapment syndrome subtypes: imaging, injections, and minimal access surgery. Neurosurg Focus 26 (2) E9: (2009). (PMID: 19323602)
Filler AG. Minimal access nerve surgery and interventional MRI. Neurosurgery 65: (4 Suppl), pA212-A221 (2009). (DOI: 10.1227/01.NEU.0000346253.89837.6C) (PMID: 19927071)
Filler AG. MR Neurography and Diffusion Tensor Imaging: Origins, history, & clinical impact of the first 50,000 cases with an assessment of efficacy and utility in a prospective 5,000 patient study group. Neurosurgery 65: (4 Suppl), pA29-A43 (2009). (DOI: 10.1227/01.NEU.0000351279.78110.00) (PMID: 19927075)
Filler AG. The history, development and impact of computed imaging in neurological diagnosis and neurosurgery: CT, MRI, DTI. Internet Journal of Neurosurgery, 7:(1) (2010)
Filler AG, Lever AML, Bacon M, Munglani R, Abell C, Frederickson M, and Whiteside G. Tri-partite complex for axonal transport drug delivery achieves pharmacological effect. BMC Neuroscience 11:8 (2010). (DOI: 10.1186/1471-2202-11-8) (PMID: 20085661)
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